The work by Begum et al. [71], who looked at methylation profiles of a slightly larger set of 15 genes and then selected the six most sensitive and specific genes for predicting lung cancer risk (APC, CDH1, MGMT, DCC, RASSF1A and AIM1), clearly shows evidence that a more global methylome approach could lead to a more sensitive (75%) and specific (73%) biomarker of lung cancer risk from serum DNA [71]. Here, RASSF1 is linked to lung cancer.