Therefore, in the present study, we genotyped TNF-α promoter SNPs [−308G > A (rs1800629), -857C > T (rs1799724), -863C > A (rs1800630), and -1031T > C (rs1799964)] and evaluated their associations with risk of HPV16-associated OSCC in 325 OSCC patients and 335 cancer-free controls, all of whom were non-Hispanic whites. Here, TNF is linked to cancer.