AKT1 and Emery-Dreifuss muscular dystrophy 2, autosomal dominant: These authors subsequently demonstrated that (i) Akt activated by insulin phosphorylates lamin A/C at Ser-404 in C2C12 mouse myoblasts, but this phosphorylation cannot be detected in primary cells from an EDMD-2 patient; (ii) Akt phosphorylation at Ser-404 targets the precursor prelamin A for degradation; and (iii) Akt regulates transcription of the gene encoding lamin A (LMNA) [8,9,29].