In summary, we demonstrated that BBR exhibited anti-proliferative and pro-apoptotic activities in NSCLC cells through simultaneous modulation of the AP-2/hTERT, HIF-1α/VEGF, NF-κB/COX-2, Raf/MEK/ERK, PI3K/AKT and caspase/cytochrome-c signaling pathways. The gene discussed is CYCS; the disease is non-small cell lung carcinoma.