In recent years, therapies selectively target cell signaling pathways, such as EGFR, VEGF, KRAS, BRAF, ALK, HER2, MET, TITF-1, p53, LKB1 and many others, not only provided a better understanding of NSCLC carcinogenesis, but also used as prognostic factors or targets for individualizing therapy [3]. This evidence concerns the gene VEGFA and non-small cell lung carcinoma.