Hence, in the present study we propose to do a comparative assessment of interleukin-6 (IL-6), interleukin-8 (IL-8), TNF-α and sCD163 with C-reactive protein (CRP) before antibiotics, for the early identification of neonatal sepsis and serial estimations at different time intervals to check the prognosis. The gene discussed is CRP; the disease is Neonatal sepsis.