As stimulation of intact glomeruli and mesangial cells with soluble TNF did not reveal any exclusively TNFR2-mediated inflammatory effects, potential mechanisms leading to protection from GN in Tnfr2-deficient mice [20] may involve activation of renal cell-expressed TNFR2 by membrane-bound TNF. Here, TNFRSF1B is linked to ganglioneuroma.