Examining the real-world evidence and our model of Demark, Tables S1 and S2 in File S1 show that our model matched the adult population mean HbA1c, the prevalence of diagnosed type 2 diabetes among adults stratified by gender and age, the annual incidence of type 2 diabetes, the mean HbA1c of individuals with type 2 diabetes stratified by age, and the prevalence of patients taking oral diabetic agents and insulin. Here, INS is linked to type 2 diabetes mellitus.