CYP3A4 and open-angle glaucoma: ESR1, aldo-keto reductase family 1, member D1 (AKR1D1), cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), catechol-O-methyltransferase (COMT), and steroid sulfatase (microsomal), isozyme S (STS) were significantly (permuted gene p values of <0.001, 0.05, 0.01, <0.001, and <0.001, respectively) associated with POAG overall among women (Table 2).