COMT and open-angle glaucoma: Although one COMT SNP (rs2531697) showed particularly strong p values for association with HPG in women (p=4.10E-05), the SNP would not remain significant if one accounted for the multiple comparisons made in this analysis (903 SNPs stratified by gender and IOP yielding a corrected significance level of 1.85E-05); however, our pathway analysis points to a large number of COMT SNPs significant for POAG and its subtypes among women.