A prior meta-analysis of the CYP1BI SNPs in association with POAG consisting of 1,953 cases and 1,341 controls that found no significant association [56] is largely consistent with our larger study (3,108 cases and 3,430 controls), which found no association between the CYP1B1 aggregate of SNPs and POAG among men and women together (permuted gene p=0.098). Here, CYP1B1 is linked to open-angle glaucoma.