A spectrum of cancers, including ovarian, bladder, gastric, pancreatic, colorectal, skin and lung, have been reported with various XRCC1 polymorphisms (Cheng et al., 2012; Chiyomaru et al., 2012; Muñiz-Mendoza et al., 2012; Nakao et al., 2012; Wang et al., 2012; Zhi et al., 2012). The gene discussed is XRCC1; the disease is cancer.