To investigate whether stromal AKT activation is important in oro-pharyngeal tumours, matched normal and tumour samples from 34 oro-pharyngeal tumour samples were stained with pAKT (Ser 473) as a readout of AKT activity [15] and Fibroblast Specific Protein 1 (FSP1) as a marker for stromal fibroblasts (Figure 1A). Here, S100A4 is linked to neoplasm.