CDKN1A and diffuse large B-cell lymphoma: Interestingly, when co-treated with VPA (0.5 mM) and temsirolimus (1 nM), MYC-expressing diffuse large B-cell lymphoma (DLBCL) cell line DB was also sensitive to autophagy (Figure 5E), in consistent with increased expression of CDKN1A and CDKN1B, as well as decreased expression of p-AKT, p-MTOR and MYC oncoprotein (Figure 5F).