CD4+ T-cell counts positively correlated with the proportions of bulk (p = 0.04, Spearman r = 0.28) and CD56dim (p = 0.03, Spearman r = 0.31) NK cells expressing Tim-3 in subjects with untreated chronic progressive and controlled HIV-1 infection (Additional file2). This evidence concerns the gene CD4 and HIV-1 infection.