Gleason and colleagues reported diminished expression of Tim-3 on NK cells from patients undergoing allogeneic hematopoietic stem cell transplantation for the treatment of leukemia, and lower expression correlated with impaired IFN-γ production, further supporting a role for Tim-3 signaling in enhancing cytokine production by NK cells[20]. This evidence concerns the gene HAVCR2 and leukemia.