Interestingly, the protein level of cyclin D1, a CDK regulator important for regulating the G1/S transition, was downregulated in LN18 and T98G glioma cells transfected with miR-329 mimic, but increased in the cells transfected with miR-329 inhibitor, compared with control cells (Figure 4B). This evidence concerns the gene CCND1 and glioma.