E2F1 and glioma: It has been shown that the low expression of miR-106a in human glioma specimens is significantly correlated with high levels of E2F1 protein and high-grade glioma, E2F1 is a direct functional target of miR-106a, the suppressive effect of miR-106a on the glioma may result from inhibition of E2F1 via post-transcriptional regulation [23].