RAN and neoplasm: Of the 40 genes, 6 genes (KIT, RAN, RAB39B, RAB9A, RAB37 and TERT), including proto-oncogenes, have been implicated in enhanced tumour growth, and 8 genes (ETS1, SPI1, ETV6, EPHA7, EPHA5, EPHB2, EPHA10 and TRIO) in invasion/metastasis and 3 genes (APC, NF1 and MEN1) in tumour suppression (Table 2).