PBX3 and acute myeloid leukemia: Some of the miR-181c target genes are associated with prognosis and drug response, ones such as PBX3, HSP90B1, NMT2, and RAD21. For example, AML patients with intermediate- to poor-prognosis subtypes, who had lower expression of miR-181, conversely showed an increased level of PBX3[16].