The chemokine (C-C motif) ligand 2 (CCL2) protein (also known as macrophage chemoattractant protein 1, or MCP-1) is well-recognized for its ability to mediate macrophage recruitment and migration to sites of inflammation in rheumatoid arthritis, multiple sclerosis, traumatic brain injury, stroke and Alzheimer disease (AD) [1-7]. This evidence concerns the gene CCL2 and multiple sclerosis.