Since in the PCOS affected animals the mechanisms regulating GnRH secretion are altered[17,18], and these alterations may be modified by vagotomy procedures, present results suggest that neural signal originating from each ovary would indicate the physiological conditions of the ovaries to the CNS, which in turn participates in the regulation of GnRH secretion[37]. Here, GNRH1 is linked to polycystic ovary syndrome.