Several hypothesis have been proposed to explain the etiology of the PCOS, including failings in the pulsatile secretion of gonadotropin release hormone (GnRH) and the resulting deficiencies in ovarian sex steroid synthesis or metabolism[7]; the hyper-activation of the sympathetic fibers arriving to the ovary via the SON[21,31]; and kisspetin related mechanisms[32]. The gene discussed is GNRH1; the disease is polycystic ovary syndrome.