Relevant to the present results, selective induction of HK2 and pyruvate dehydrogenase kinase-1 (PDK1) by hypoxia (and HIF-1α and c-myc) was observed in a previous study of human P493-6 B-lymphoblastoid cells, a model for human Burkitt’s lymphoma [55]. Here, HK2 is linked to Burkitt lymphoma.