Using real-time PCR and immunohistochemistry analysis, we analysed TLR2 expression in 39 paired samples (tumour and adjacent noncancerous tissues from the same patient) and found that TLR2 expression is significantly up-regulated in CRC tissues (Figure 1A and Additional file 1: Figure S1; ***p < 0.001). This evidence concerns the gene TLR2 and colorectal carcinoma.