In day-to-day clinical practice, a multimodal strategy (Remission Clinic) of dual RAS inhibition with ACE inhibitors and ARBs up-titrated to maximum tolerated doses, intensified BP control, amelioration of dyslipidaemia by statins, smoking cessation and healthy lifestyle implementation, was found to safely and effectively achieve remission or regression of proteinuria and stabilize kidney function in most CKD patients with heavy proteinuria despite ACE inhibitor therapy, and almost fully prevent progression to ESRD [89]. The gene discussed is ACE; the disease is inherited lipid metabolism disorder.