The Combination Angiotensin Receptor Blocker and Angiotensin-Converting Enzyme Inhibitor for Treatment of Diabetic Nephropathy (VA NEPHRON-D) multicentre trial to assess the effect of the combination of losartan and lisinopril compared with losartan alone, on the progression of kidney disease in 1,850 patients with diabetes and overt proteinuria, was terminated recently for similar reasons to those of the ALTITUDE study [61,69]. This evidence concerns the gene ACE and kidney disorder.