In 17 patients with coronary artery disease (CAD) and SBP >130 mmHg on ACE inhibitor or ARB therapy, addition of aliskiren 150 mg for 6 weeks significantly reduced SBP and plasma renin activity but did not affect plasminogen activator inhibitor-1, fibrinogen, or D-dimer levels, suggesting that dual RAS inhibition does not have any effect on biomarkers of the fibrinolytic system [106]. This evidence concerns the gene ACE and coronary artery disorder.