FBLN1 and diabetes mellitus: Patients with diabetes that were not treated with metformin had plasma fibulin-1 levels comparable to the controls, 103 ± 34 vs. 100 ± 30 μg/mL, p = 0.75 (Figure 1B), whereas metformin-treated patients had markedly lower fibulin-1 levels than controls, 88 ± 23 vs. 109 ± 29 μg/mL, p < 0.001 (Figure 1C).