Similarly, Jiao et al. proposed that HMGB1 could function as a tumor suppressor and radiosensitizer in breast cancer [25] because oxidized HMGB1 increased the cytotoxicity of these agents and induced apoptosis via the mitochondrial pathway or the caspase-9/-3 intrinsic pathway [26]. The gene discussed is HMGB1; the disease is breast carcinoma.