Because the association between A-FABP level and CAD severity was attenuated in the subgroup of patients with HF and the predictive value of A-FABP to HF persisted after adjustment for SRS and SSS, we believe that HF-related metabolic disarrangement, rather than CAD severity, may be a more important determinant of A-FABP levels in CAD patients with HF. This evidence concerns the gene FABP4 and hydrops fetalis.