CD8+ T cells from the spleens of non tumor-bearing (naïve), IgG2a-pretreated animals (control), or sTGF-βR-pretreated animals (TGF-β-blockade) were mixed with AB12 cells (in a 3:1 ratio of CD8+ T cell:tumor cell) and injected into the flanks of different, non tumor-bearing animals. The gene discussed is TGFB1; the disease is neoplasm.