Initial sensitization of CD8+ T cells typically requires 4 steps: migration of DCs into tumor nodules, ingestion and subsequent internal-processing of apoptotic cancer cell debris, presentation of processed peptide fragments in both MHC class I and class II complex clefts (by activated DCs), and migration of the activated DCs into TDLNs where T cell-sensitization occurs. This evidence concerns the gene CD8A and neoplasm.