In LN229 and LN308 glioma cells, both inhibition of CXCR4 by AMD3100 and shRNA-mediated knockdown of CXCR7 expression diminished migration towards SDF-1α and reduced levels of SDF-1α-induced phosphorylation of ERK1/2 and Akt. This evidence concerns the gene CXCL12 and central nervous system cancer.