It is interesting that while both CXCR4 and CXCR7 are required for SDF-1α-induced migration of hypoxic glioma cells, blocking both CXCR4 and CXCR7 does not provide an additive effect, either with regards to migration assays or phosphorylation of ERK1/2 and Akt. Here, MAPK3 is linked to central nervous system cancer.