As a first step to elucidate molecular signaling pathways mediated by CXCR7, we tested whether SDF-1α induces phosphorylation of ERK1/2, Akt and FAK in LN229 and LN308 glioma cells that demonstrate CXCR7-mediated migration towards SDF-1α. This evidence concerns the gene CXCL12 and glioma.