ERBB2 and breast carcinoma: These include trastuzumab as first-line treatment in patients with locally recurrent or metastatic HER2-positive breast cancer (NCT01269346), lapatinib in HER2-positive MBC pre-treated with trastuzumab (NCT01534455), and carboplatin as neoadjuvant therapy in patients with TNBC (NCT01372579).