Conversely, Nrf2 KO mice models of neurological disorders including Parkinson's disease [35], spinal cord injury [37], traumatic brain injury [40], intracerebral hemorrhage [42], and epilepsy [43] exhibited increased susceptibility to neurological oxidative damages but did not maintain any benefits from the protective effects of SUL. This evidence concerns the gene NFE2L2 and intracerebral hemorrhage.