Therefore, in this study we examined whether SUL can suppress Aβ25–35-induced oxidative damage and cell death in human neuroblastoma SH-SY5Y cells via augmentation of antioxidant defense capacity by activation of NF-E2-related factor 2 (Nrf2) and the subsequent expression of antioxidant and phase II detoxification enzymes which play key roles in inhibiting ROS production and oxidative damages. This evidence concerns the gene NFE2L2 and neuroblastoma.