Furthermore, activation of the Nrf2-ARE pathway is able to protect against brain injuries in the animal models of neurodegenerative diseases [34, 35], spinal cord injury [36–38], focal cerebral ischemia [39], hypoxia-ischemic injury [14], traumatic brain injury [40], subarachnoid [41] or intracerebral hemorrhage [42], or epilepsy [43]. The gene discussed is NFE2L2; the disease is neurodegenerative disease.