The lack of association between CRP and endothelial function in overweight and obese women brings new questions and hypotheses: 1), it is possible that the level of eNOS dysfunction associated with increased CRP is not enough to lead to macroscopic changes and compromise vasodilatation; 2), considering that the increase in CRP was moderate and that endothelial function was considered within normal limits, maybe they were really a population of obese with no impaired vascular function enough to change an imaging method of assessing subclinical atherosclerosis. Here, CRP is linked to atherosclerosis.