This study explores the effect of acupuncturing Neiguan (PC-6) on myocardial ischemia treatment and its working mechanism, based on the existing theories and research findings on the effect of acupuncture on myocardial ischemia and employing immunoblotting technique to observe the protein expressions of CFTR and CLC-2 CL− channels. Here, CFTR is linked to myocardial ischemia.