INS and diabetes mellitus: Moreover, since significant differences have been observed between DM and DR group (duration of diabetes, level of hyperlipidemia, and percentage of insulin therapy), multivariate logistic regression analysis was performed to assess the genetic role of DR by considering these factors, which showed that I62V and R150R remain significant when adjusted for all these factors, implying that CFH and CFB polymorphisms are independent genetic factors for susceptibility to DR.