The common characteristics are that (1) the expressions of TLR2 and TLR4 increase at the beginning of reperfusion following cerebral ischemia and last a long time; (2) the methods inhibiting the expression of TLR2 and TLR4 in brain tissue have significantly suppressed neurological deficits and alleviated brain damage caused by cerebral ischemia and reperfusion; (3) the expressional level of TLR2 and TLR4 influenced the production of multiple cytokines which participate in inflammatory signal pathway and decided the outcome of cerebral ischemia and reperfusion. Here, TLR4 is linked to Cerebral ischemia.