Mild treadmill training at three weeks prior to brain ischemia, or at day 5 reperfusion following ischemia, contributed to the recovery of neurological dysfunction via inhibiting the mRNA level and protein concentration of TLR2 and TLR4 and their downstream molecules (such as MyD88 and NF-κB) in rat brain tissue [65, 66]. Here, TLR4 is linked to brain ischemia.