It is reported that downregulation of E-cadherin (36–39), weakened expression (39) or overexpression of N-cadherin (40), overexpression of β-catenin (36–38), overexpression of vimentin (41,42), overexpression of Snail (36,43), overexpression of Slug (36) and overexpression of TWIST (36,39) are poor prognosis factors for HCC. This evidence concerns the gene TWIST1 and hepatocellular carcinoma.