It is reported that downregulation of E-cadherin (36–39), weakened expression (39) or overexpression of N-cadherin (40), overexpression of β-catenin (36–38), overexpression of vimentin (41,42), overexpression of Snail (36,43), overexpression of Slug (36) and overexpression of TWIST (36,39) are poor prognosis factors for HCC. This evidence concerns the gene CDH1 and hepatocellular carcinoma.