CDH2 and hepatocellular carcinoma: It is reported that downregulation of E-cadherin (36–39), weakened expression (39) or overexpression of N-cadherin (40), overexpression of β-catenin (36–38), overexpression of vimentin (41,42), overexpression of Snail (36,43), overexpression of Slug (36) and overexpression of TWIST (36,39) are poor prognosis factors for HCC.