Knockdown of JAG1 or ΔNp63 resulted in the upregulation of proliferation-associated markers (FoxM1 and CXCL1) and markers commonly associated with basal-like breast cancer (p-cadherin, CXCL1 and CTPS1) [Figure 4B (iii) and (iv), Supplementary Figure S5B (iii) and (iv)]. The gene discussed is JAG1; the disease is breast carcinoma.