TNK2 and posterior cortical atrophy: In androgen-depleted conditions, tyrosine kinase, non-receptor, 2 (TNK2 or ACK1), SRC, and erythroblastic leukemia viral oncogene homolog 2 (ERBB2 (HER-2/Neu)) tyrosine kinase activity can restore AR function in PCa cells [66,68,72,102].