One example of this is an inducible triple transgenic autochthonous mouse model of lung adenocarcinoma (CCSP-rtTA/tetO-KrasG12D/Twist1-tetO7-luc), which our group has used recently to show the radiosensitizing properties of Hedgehog pathway inhibition on the tumor microenvironment [22]. Here, TWIST1 is linked to lung adenocarcinoma.