VEGFA and central nervous system cancer: As the key regulatory systems in angiogenesis of gliomas, VEGF and VEGF receptors are targeted mainly in radionuclide-based imaging and recently assessed by a molecular MR imaging probe, anti-VEGF receptor-2 monoclonal antibody conjugated with a gadolinium-based contrast agent, in a rat C6 glioma model by He et al. [91].