As shown in Figure 5, the slices from control rats that were preincubated with 30 μg/mL of insulin had significant increases in both [3H]ES (Figure 5(a)) and [3H]PAH (Figure 5(b)) uptakes compared to the slices without insulin, indicating that upregulated rOat3 function by either ES or PAH was reproduced similarly to that of previous study [27]. The gene discussed is INS; the disease is pulmonary arterial hypertension.