CAT and diabetes mellitus: Since SNE enriched polyphenols, which is known to have antioxidant activity [4, 25, 35], we then focused on renal antioxidant system and found that SNE primarily counteracts ROS at the transcriptional process by the alteration of GPx mRNA transcript in DM rats and overexpressed Cu-ZnSOD and CAT mRNA levels in normal rats (Figure 7(a)).