Hence, in this study, we selected 6 well-documented lncRNAs associated with metastasis including MALAT1 [15, 16], HOTAIR [16], NEAT-1 [25], HULC [26], MEG-3 [27], and UCA1 [28] to evaluate their expression in primary melanoma and matched lymph node metastasis tissues. This evidence concerns the gene HOTAIR and melanoma.