In the present investigation,the low frequency of TLR4 Gly299Gly/Thr399Thr (1.4%) among Baluchi infected individuals,its absence in healthy participants and thehigh frequency of Asp299Asp/Thr399Thr (80.6%)among the studied population from an area with noreport of severe malaria or mortality due to malariamight suggest an association of these genotypes withclinical symptoms of mild malaria. The gene discussed is TLR4; the disease is malaria.