In the current immunogenetic study, weassessed the TLR4 genotypes formed by the two common single nucleotide polymorphisms(SNPs) (Asp299Gly and Thr399Ile) in the co-segregate state in BaluchiPlasmodium falciparum infected and healthy populations from malaria hypoendemicareas of Iran. Here, TLR4 is linked to malaria.