HLA-DRB1 and type 1 diabetes mellitus: The HLA-DRB1 and -DQB1 alleles areidentified as the most important alleles which areassociated with T1D in many ethnic groups (7-9).Due to strong linkage disequilibrium between theHLA-DRB1 and -DQB1 alleles, the highest geneticrisk is conferred by their haplotypes in comparedwith particular alleles (10-16).