Also,frequencies of DRB1*03:01 allele and DRB1*03:01-DQB1*02:01 haplotype in female patientsdiagnosed in category of 6-10 years oldwere significantly more than male patients.Similar to our results, Tait et al. showed a genderdifference in T1D patients diagnosed at age< 12 years with an excess of males in DR3-/DR4+ group and females in DR3+/DR4- group(30). This evidence concerns the gene HLA-DRB1 and type 1 diabetes mellitus.