GSK-3β and β-catenin are regulated either directly or indirectly by lithium, valproate, antidepressants, and antipsychotics [8, 10, 113–117], while GSK-3β has also been identified as a target for the treatment of Alzheimer's disease [216] (Table 2). The gene discussed is GSK3B; the disease is early-onset autosomal dominant Alzheimer disease.