Alterations in serum PCSK9 levels and- or its positive correlation to LDL-C have been documented in several physiological and pathological states in which lipid levels are also affected: circulating PCSK9 follows a diurnal rhythm with cholesterol synthesis [17] and is decreased during fasting [18, 19], and PCSK9 is upregulated by the commonly prescribed lipid-lowering statins thereby blunting their effect [20–22], but PCSK9 is not correlated with LDL-C in controlled Type II diabetes and is, in fact, negatively correlated in uncontrolled Type II diabetes [23]. Here, PCSK9 is linked to type 2 diabetes mellitus.