Though the precise molecular mechanism(s) underlying exercised-induced modulation of PCSK9 may not beclear, our data suggests that the reduction in blood PCSK9 involves a posttranscriptional and/or translational event(s), given that no change in hepatic PCSK9 protein was observed between the HF and HF + EX groups. This evidence concerns the gene PCSK9 and hydrops fetalis.