MPV17 and mitochondrial DNA depletion syndrome: Likewise, several mutations in mpv17 were reported to be associated with mitochondrial DNA depletion syndrome in humans causing death during early childhood (AlSaman et al., 2012; El-Hattab et al., 2010; Navarro-Sastre et al., 2010; Spinazzola et al., 2008; Spinazzola et al., 2006; Wong et al., 2007).