Theusefulness of U-Omp16 was also assessed in a mouse model of food allergy.U-Omp16 i.n. administration during sensitization ameliorated thehypersensitivity responses of sensitized mice upon oral exposure to Cow’s MilkProtein (CMP), decreased clinical signs, reduced anti-CMP IgE serum antibodiesand modulated the Th2 response in favor of Th1 immunity. This evidence concerns the gene IGHE and food allergy.