From the 5th week, the rats from the Banded group (n = 90) were divided randomly into two groups as the BRL group [heart failure group with a β3-AR agonist called BRL37344 (4-[-[2-hydroxy-(3-chlorophenyl)ethyl-amino] phenoxyacetic acid) injection] (n = 50) and the non-BRL group (heart failure group without BRL37344 injection) (n = 40). This evidence concerns the gene ADRB3 and heart failure.