Majority of the pathways within this network were related to DNA damage response and G1/S phase transition (all p<1E-14) with the upstream converging nodes including the following genes: ATM, ATR, BRCA1, CHEK1 and NBN, and thus implicating DNA damage ATM/ATR regulation of G1/S transition pathway in the progression of dementia. This evidence concerns the gene CHEK1 and dementia.