Comparisons of individuals with and without AD-associated neuropathology also showed high levels of MDM4 and ATM gene expression as a function of increasing neuritic plaque (NP) density (F3,112 = 3.601, p = 0.016 and F3,112 = 4.802, p = 0.009, respectively) and Braak neuropathological stages (F4,112 = 3.042, p = 0.020 and F4,112 = 2.816, p = 0.029, respectively). Here, MDM4 is linked to Alzheimer disease.