We found that AZD8055 treatment rescued the HD phenotype by reducing mHtt aggregate size and density and preventing MSNs degeneration leading to normal DARPP-32 and NeuF levels in R6/2 CStS; and by reducing mHtt accumulation and soluble full-lenght mHtt in HET Hdh(CAG)150 mutant CStS. The gene discussed is PPP1R1B; the disease is Huntington disease.