MBP and multiple sclerosis: One of the most studied candidate auto-antigens in multiple sclerosis is the classic 18.5-kDa isoform of MBP, which is essential to the stability of central nervous system myelin where it plays numerous roles both in myelin development and homeostasis, acting both to adhere membrane leaflets to each other, and as a hub in protein-protein and protein-membrane interaction networks [17]–[22].