Although strong evidence indicates a causative role of VEGF in retinal neovasculation (NV), other angiogenic factors most likely stimulate NV in a parallel and concerted fashion.The finding in our study that the intraocular level of bFGF was significantly correlated with inner CMT in the patients with macular edema due to BRVO has never been reported. The gene discussed is FGF2; the disease is macular retinal edema.